This medication may temporarily sting or burn your eyes for a minute or two when applied. Eye discomfort, dry eyes, tearing, itching, or redness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Use of this medication for prolonged or repeated periods may result in a new type of eye infection (e.g., viral, fungal). Do not use it for longer than prescribed. Contact your doctor if you notice new or worsening symptoms. Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes, eye pain, staining of the eyes. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing, signs of infection (e.g., fever, persistent sore throat), easy bleeding/bruising, yellowing of the eyes/skin, dark urine. If you notice other effects not listed above, contact your doctor or pharmacist.

Before using sulfacetamide/prednisolone, tell your doctor or pharmacist if you are allergic to it; or to sulfa drugs (e.g., sulfamethoxazole), corticosteroids (e.g., hydrocortisone, prednisone), preservatives (e.g., benzalkonium chloride); or if you have any other allergies. Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (e.g., glaucoma, severely dry eyes), eye surgeries (e.g., cataract surgery), diabetes. Use caution engaging in activities requiring clear vision such as driving or using machinery because your vision may be temporarily blurred or unstable after applying this drug. Limit alcoholic beverages. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if the medications in this product pass into breast milk. Consult your doctor before breast-feeding.